"Cushlomachree" is some Irish expression I don't know the meaning of, which was used often by Mr. O'Malley in Crockett Johnson's "Barnaby" comic strip. It is pronounced "cush-la-mack-REE"
It means "pulse of my heart," and can either be a term of endearment, or (as in the case above), something akin to "my heart!!!"